Frequency of Endometrial Carcinoma in Patients with Postmenopausal Bleeding | Semantic Scholar (2024)

Doppler ultrasound is very useful diagnostic modality for diagnosing endometrial carcinoma in patients having post-menopausal bleeding in PMB women.

This study showed a high prevalence of malignant disorders in women with postmenopausal bleeding with carcinoma of cervix and endometrium having an equal contribution, and Multiparity was the most significant factor for carcinomas ofendometrium.

The use of Doppler ultrasonography in non-invasive diagnosis of endometrial carcinoma in patients presenting with post-menopausal bleeding was quite useful with good sensitivity, specificity, as well as positive and negative predictive values.

The majority of cases of PMB would be expected to be suffering from benign problems, and endometrial cancer is the most frequent malignancy in women with postmenopausal bleeding with mean age of 65years.

In carcinoma endometrium, MR-DWI has good diagnostic accuracy in the detection of myometrial invasion in patients with carcinoma endometrium keeping histopathology as the gold standard.

Patients’ preferences for diagnostic management of postmenopausal bleeding are surveyed for the first time in a double-blind, placebo-controlled study of women with high levels of HCG.

The presence of calcified lesions in the uterine cavity is highly suggestive of IUCD but retained fetal bone should be considered, although a few cases of endometrial calcification/ossification, presumably due to osseous metaplasia or heteroplasia of the endometrium, have also been reported.

Switching from tamoxifen to anastrozole treatment significantly reduced the need for a second hysteroscopy and D&C due to recurrent vagin*l bleeding or thickening of the endometrium in postmenopausal breast cancer patients with tamoxIFen-induced endometrial abnormalities.

In a patient with no obvious local cause, the emphasis should be on uterine and adnexal evaluation, and the evidence favours a conservative approach if the endometrial thicknes (ET) is < 4mm, unless there are risk factors.

Endometrial hyperplasia without atypia is likely to respond to hormonal treatment, especially in postmenopausal situation, and atypical hyperplasias should be treated with total hysterectomy.

The median age of menopause in this study is lower than that reported for Caucasian, Thai and Malaysian women; similar to figures from Africa and South America; but higher than those reported from Iran, Egypt, Turkey and UAE.

ERT use and obesity, both established endometrial cancer risk factors and markers of estrogen exposure, substantially modify the association between tamoxifen use and endometrian cancer risk among patients with breast cancer.

Pipelle sampling detected only 1 of the 2 cases of endometrial cancer in this study, and Registrars and resident doctors were more likely to sample insufficiently.

...

...